|ISSN No. 1606-7754 Vol.8 No.3 December 2000|
Dyslipidaemia in type 2 diabetes mellitus
Harsh Udawat, RK Goyal
Department of Medicine, JLN Medical College and AG Hospital, Ajmer
Macrovascular diseases like coronary heart disease (CHD), cerebrovascular accidents (CVA) and peripheral vascular disease (PVD) are the leading causes of mortality and morbidity in type 2 diabetes mellitus (DM). Type 2 DM is associated with two-to-four fold excess risk of CHD, higher case fatality rate and sudden cardiac deaths. There is also a five-fold increase in risk of fatal stroke and a significantly increased risk of atherosclerosis-induced gangrene of lower limbs as compared to non-diabetic individuals.1-5 The increased atherosclerosis risk in DM is attributed to the high prevalence of several predisposing factors like obesity, hypertension, insulin resistance and dyslipidaemia in these patients. Although the degree of glycaemia in diabetic patients is strongly related to the risk of microvascular disease (retino-pathy, nephropathy), the relationship of glycaemia with macrovascular disease in type 2 DM is less certain.6 There is enough evidence in literature7-11 to support the beneficial effect of lowering of serum lipids in retarding macrovascular disease. It is important to realise that hyperlipidaemia and the resultant macrovascular disease can develop even in the 'prediabetic phase' of type 2 DM.12 Hence, early detection and correction of dyslipidaemic state is essential in the management of diabetic patients.